Black Mesa can refer to:
- Black Mesa - the corporation employing Gordon Freeman in Half-Life
- Black Mesa Research Facility - the headquarters of the Black Mesa corporation
- Black Mesa Incident - the infamous incident at the facility that permanently breached the wall between Earth and the Xen border world and triggered the Portal Storms
- Black Mesa Personnel - the Black Mesa employees
- Black Mesa Science Team - the scientists
- Black Mesa Security Force - the security guards
- Black Mesa Announcement System - the announcement system used in the Black Mesa facility
- Black Mesa Transit System - the monorail network running throughout the Black Mesa facility
- The Mesa Times - the local Black Mesa newspaper
- Black Mesa East - the Resistance base on the outskirts of City 17
- Black Mesa East (chapter) - the Half-Life 2 chapter during which Black Mesa East is visited
- Black Mesa (game) - the mod/game that remade Half-Life using the Source engine
- Operation Black Mesa - a mod/game remaking Half-Life: Opposing Force from Source engine
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